Back to search

Article

Phylo-Plex: A phylogenetically informed, low-cost amplicon sequencing platform for deployable high-resolution genomic epidemiology

2025-02-25

Abstract excerpt

Genomic pathogen surveillance is a powerful tool for public health and research, but is costly and unachievable in low-resource settings. Most sub-genomic typing methods sacrifice resolution whilst remaining costly. We developed “Phylo-Plex”, a novel approach that identifies information-rich genomic regions to maximise phylogenetic information whilst minimising the number of regions. Applied to Treponema pallidum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0e396bfb-976a-5aac-a38a-df8cc3fd53f7
DOI
10.1101/2025.02.19.25322526
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Phylo-Plex: A phylogenetically informed, low-cost amplicon sequencing platform for deployable high-resolution genomic epidemiologyDOI 10.1101/2025.02.19.25322526
Advancing Chlamydia trachomatis genomic surveillance and research with a novel core-genome MLST (cgMLST) approachSemantic proximity
A new highly discriminatory typing scheme for Treponema pallidum reveals similar levels of genetic variability across lineages.Semantic proximity
<i>Treponema pallidum</i> subsp. <i>pallidum</i> genetic population structure and relevance to syphilis prevention and treatmentSemantic proximity
Phylodynamic modelling of bacterial outbreaks using nanopore sequencingSemantic proximity
Development and Validation of a Burkholderia pseudomallei Core Genome Multilocus Sequence Typing Scheme To Facilitate Molecular SurveillanceSemantic proximity
Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins.Semantic proximity
Time Required for Nanopore Whole-Genome Sequencing of Neisseria gonorrhoeae for Identification of Phylogenetic RelationshipsSemantic proximity
A new typing scheme demonstrates high discriminatory power for <i>Treponema pallidum</i> subspeciesSemantic proximity
Pathotypr: harmonised MTBC lineage assignment and resistance-associated variant detection for genomic surveillanceSemantic proximity
Biological causes and impacts of rugged tree landscapes in phylodynamic inferenceSemantic proximity
A comprehensive genomics solution for HIV surveillance and clinical monitoring in a global health settingSemantic proximity
Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study.Semantic proximity
Select a neighboring publication to make it the new centre.