Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins.

doi:10.1128/jb.00159-25

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Article

Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins.

Journal of bacteriology - 21 Aug 2025

Bettin Everton B, Aghakhanian Farhang, Hennelly Christopher M, Chen Wentao, Davenport Timothy C, Hackl Simon T, Grassmann Andre A, Vargas-Cely Fabio, Silva Sebastián, García-Luna Jonny A, Ramirez Lady G, Jiang Yinbo, Yang Ligang, Zheng Heping, Yang Bin, Pospíšilová Petra, Šmajs David, Matoga Mitch M, Hoffman Irving F, López-Medina Eduardo, Nieselt Kay, Moody M Anthony, Seña Arlene C, Salazar Juan C, Parr Jonathan B, Caimano Melissa J, Hawley Kelly L, Radolf Justin D

Abstract excerpt

Knowledge of Treponema pallidum subspecies pallidum (TPA) outer membrane protein (OMP) sequence variability is essential for understanding spirochete proliferation within endemic populations as well as the design of a globally effective syphilis vaccine. Our group has identified extracellular loops (ECLs) of TPA BamA (TP0326) and members of the FadL family (TP0548, TP0856, TP0858, TP0859, and TP0865) as potential...

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PMID: 40802283
DOI: 10.1128/jb.00159-25
PMCID: PMC12369335

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