A new highly discriminatory typing scheme for Treponema pallidum reveals similar levels of genetic variability across lineages.

doi:10.1128/mbio.00358-26

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Article

A new highly discriminatory typing scheme for Treponema pallidum reveals similar levels of genetic variability across lineages.

mBio - 13 May 2026

Pla-Díaz Marta, Giacani Lorenzo, Tantalo Lauren C, Bose Mahashweta, Reid Tara B, Marra Christina M, Šmajs David, Pospíšilová Petra, Janečková Klára, Kawahata Takuya, Banno Fumiya, Vilfort Kendra, Cao Weiping, Pillay Allan, Noda Angel, Bosshard Philipp P, Chen Marcus, Mitjà Oriol, Schuenemann Verena J, Hackl Simon, Nieselt Kay, Hernández-Bel Pablo, Ocete M Dolores, Arora Natasha, González-Candelas Fernando

Abstract excerpt

The global resurgence of treponematoses, particularly syphilis, poses a growing public health challenge. Despite advances in sequencing technologies, obtaining complete Treponema pallidum genome sequences for epidemiological studies remains challenging due to clinical sampling and methodological constraints. There is, therefore, a need for rapid, cost-effective, and accessible typing methods. Based on the...

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PMID: 41949329
DOI: 10.1128/mbio.00358-26
PMCID: PMC13170356

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