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Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD) dose-dependently shifts the gut microbiome consistent with the progression of steatosis to steatohepatitis with fibrosis

2021-11-02

Abstract excerpt

Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. TCDD induces hepatic fat accumulation and increases levels of secondary bile acids including taurolithocholic acid and deoxycholic acid, microbial modified bile acids involved in h...

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Literature Corpus work
0e3840d8-2587-5b22-9d33-86bdd0b9b44b
DOI
10.1101/2021.11.02.466980
Open publication

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Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD) dose-dependently shifts the gut microbiome consistent with the progression of steatosis to steatohepatitis with fibrosisDOI 10.1101/2021.11.02.466980
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