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2,3,7,8-Tetrachlorodibenzo- <i>p</i> -dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression

2024-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Epidemiological evidence suggests an association between dioxin and dioxin-like compound (DLC) exposure and human liver disease. The prototypical DLC, 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), has been shown to induce the progression of reversible hepatic steatosis to steatohepatitis with periportal fibrosis and biliary hyperplasia in mice. Although the effects of TCDD toxicity are mediated...

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Literature Corpus work
9b160165-1c5e-5a41-b8e9-624c9cc7e245
DOI
10.1101/2024.10.22.619714
Open publication

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