Article

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126

2018-02-03

Abstract excerpt

Chemical pollutant exposure is a risk factor contributing to the growing epidemic of nonalcoholic fatty liver disease (NAFLD) affecting human populations that consume a Western diet. Although it is recognized that intoxication by chemical pollutants can lead to NAFLD, there is limited information available regarding the mechanism by which typical environmental levels of exposure can contribute to the onset of this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e21f7b99-8064-55bf-b652-e35c1bfed5b7
DOI: 10.1101/259093

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126DOI 10.1101/259093Read

Mining Public Toxicogenomic Data Reveals Insights and Challenges in Delineating Liver Steatosis Adverse Outcome PathwaysSemantic proximity Read

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models.Semantic proximity Read

High‐Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver DiseasesSemantic proximity Read

PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth—a translational research frameworkSemantic proximity Read

PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read

Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver diseaseSemantic proximity Read

Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse modelSemantic proximity Read

Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroidsSemantic proximity Read

Genome-Scale Metabolic Modeling Predicts Per- and Polyfluoroalkyl Substance-Mediated Early Perturbations in Liver MetabolismSemantic proximity Read

Unraveling the Molecular Links between Benzopyrene Exposure, NASH, and HCC: An Integrated Bioinformatics and Experimental StudySemantic proximity Read

Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitisSemantic proximity Read

Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health ThreatSemantic proximity Read