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Article

TCDD modulation of gut microbiome correlated with liver and immune toxicity in streptozotocin (STZ)-induced hyperglycemic mice.

Toxicology and applied pharmacology - 1 Aug 2016

Lefever Daniel E, Xu Joella, Chen Yingjia, Huang Guannan, Tamas Nagy, Guo Tai L

Abstract excerpt

An increasing body of evidence has shown the important role of the gut microbiome in mediating toxicity following environmental contaminant exposure. The goal of this study was to determine if the adverse metabolic effects of chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure would be sufficient to exacerbate hyperglycemia, and to further determine if these outcomes were attributable to the gut...

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Identifiers

PMID: 27221631
DOI: 10.1016/j.taap.2016.05.016
PMCID: PMC5694619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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