Article

Engineering butyrate-producing Lachnospiraceae to treat metabolic disease

2025-11-09

Abstract excerpt

Engineering native gut bacteria offers a route to persistent, programmable therapeutics, yet many dominant taxa remain genetically intractable. Lachnospiraceae are a prevalent and abundant family in the human gut microbiome, possessing metabolic functions generally associated with health 1 . Despite their promise as engineered live biotherapeutics, genetic manipulation of Lachnospiraceae remains challenging. Here...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 614044e9-3280-569f-802d-edc8e82dc448
DOI: 10.1101/2025.11.08.687059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering butyrate-producing Lachnospiraceae to treat metabolic diseaseDOI 10.1101/2025.11.08.687059Read

Therapeutic engineering of the gut microbiome using synthetic biology and metabolic tools: a comprehensive review with E. coli Nissle 1917 as a model case studySemantic proximity Read

Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity.Semantic proximity Read

Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome.Semantic proximity Read

Ecology and engineering to modify the bile acid output of a defined microbial communitySemantic proximity Read

Comparative genomics and physiology of the butyrate-producing bacterium Intestinimonas butyriciproducens.Semantic proximity Read

A durably colonizing engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitisSemantic proximity Read

Genomic and functional characterization of a Butyricicoccus porcorum strain isolated from human gut microbiotaSemantic proximity Read

Genetic Engineering of Resident Bacteria in the Gut MicrobiomeSemantic proximity Read

Mining Microbial Transcriptomes to Engineer Cell-Based Bacterial Biosensors in Gut-Resident BacteroidaceaeSemantic proximity Read

From probiotic chassis to modification strategies, control and improvement of genetically engineered probiotics for inflammatory bowel diseaseSemantic proximity Read

A systematically biosynthetic investigation of lactic acid bacteria reveals diverse antagonistic bacteriocins that potentially shape the human microbiomeSemantic proximity Read

<i>Eubacterium rectale</i> detoxification mechanism increases resilience of the gut environmentSemantic proximity Read