Article

mRNA Therapy for Alport Syndrome

2026-01-21

Abstract excerpt

Alport syndrome is caused by mutations in the type IV collagen genes COL4A3, COL4A4, and COL4A5 which are expressed in podocytes in the glomerulus of the kidney. Mutation of these genes disrupts blood filtration by the kidney leading to proteinuria and kidney failure. There is no cure for Alport Syndrome. Current therapies do not treat the genetic cause of the disease, but instead aim to delay the disease by red...

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Literature Corpus work: b0ebbd98-71a9-582a-8763-baeefe5c8b95
DOI: 10.64898/2026.01.20.700554

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