Article

The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers’ Disease

2023-07-02

Abstract excerpt

Alpers’ syndrome is an early-onset neurodegenerative disorder usually caused by biallelic pathogenic variants in the gene encoding the catalytic subunit of polymerase-gamma (POLG), which is essential for mitochondrial DNA (mtDNA) replication. The disease is progressive, incurable, and inevitably it leads to death from drug-resistant status epilepticus. The neurological features of Alpers’ syndrome are intractable...

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Literature Corpus work: cdfed909-5fff-55f9-966b-9dcc5727b6a7
DOI: 10.1101/2023.07.02.547346

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