Article

Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in <i>C. elegans</i>

2021-10-15

Abstract excerpt

Caloric restriction increases lifespan across species and has health benefits in humans. Because complying with a low-calorie diet is challenging, here we investigated pharmacological interventions mimicking the benefits of caloric restriction. Searching for compounds that elicit a similar gene expression signature to caloric restriction, we identified rilmenidine, an I1-imidazoline receptor agonist and prescripti...

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Literature Corpus work: 0dfd8749-4cc7-5c8a-b4c6-af52f973eddf
DOI: 10.1101/2021.10.13.464294

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