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Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way.

Molecular and cellular biochemistry - 1 Feb 2017

Ding Ai-Jun, Wu Gui-Sheng, Tang Bin, Hong Xuechuan, Zhu Michael X, Luo Huai-Rong

Abstract excerpt

With the growth of aging population, there is increasing demand to develop strategy to improve the aging process and aging-related diseases. Benzimidazole and its derivatives are crucial heterocyclic backbone of many drugs and compounds with diverse therapeutic applications, including alleviation of aging-related diseases. Here, we investigate if the benzimidazole derivative n-butyl-[1H]-benzimidazol-2-amine...

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Identifiers

PMID: 27854075
DOI: 10.1007/s11010-016-2884-x

Genes

TRPC4
TRPC5

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