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Article

Chemical activation of a food deprivation signal extends lifespan.

Aging cell - 1 Oct 2016

Lucanic Mark, Garrett Theo, Yu Ivan, Calahorro Fernando, Asadi Shahmirzadi Azar, Miller Aaron, Gill Matthew S, Hughes Robert E, Holden-Dye Lindy, Lithgow Gordon J

Abstract excerpt

Model organisms subject to dietary restriction (DR) generally live longer. Accompanying this lifespan extension are improvements in overall health, based on multiple metrics. This indicates that pharmacological treatments that mimic the effects of DR could improve health in humans. To find new chemical structures that extend lifespan, we screened 30 000 synthetic, diverse drug-like chemicals in Caenorhabditis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27220516
DOI: 10.1111/acel.12492
PMCID: PMC5013014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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