Article

Elevating Neuronal <i>CYLD</i> Causes Frontotemporal Dementia (FTD)-Relevant Behavioral and Physiological Deficits

2026-02-26

Abstract excerpt

Frontotemporal dementia (FTD), a leading form of presenile dementia disrupting behavior, language and/or movement, is linked to mutations of a number of genes, including CYLD that encodes a Lys63 (K63) deubiquitinating enzyme. Among several CYLD variants found in FTD patients, a gain-of-function missense mutant, M719V, has been proposed to be pathogenic, but its pathogenicity in vivo and the underlying mechanism...

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Literature Corpus work: 0dde5197-5405-5113-a87d-dbcd33dce567
DOI: 10.64898/2026.02.24.707507

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