Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.

Neuropathology and applied neurobiology - 1 Apr 2023

van Hummel Annika, Sabale Miheer, Przybyla Magdalena, van der Hoven Julia, Chan Gabriella, Feiten Astrid F, Chung Roger S, Ittner Lars M, Ke Yazi D

Abstract excerpt

AIMS: Amyotrophic lateral sclerosis (ALS) is characterised by a progressive loss of upper and lower motor neurons leading to muscle weakness and eventually death. Frontotemporal dementia (FTD) presents clinically with significant behavioural decline. Approximately 10% of cases have a known family history, and disease-linked mutations in multiple genes have been identified in FTD and ALS. More recently, ALS and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Frontotemporal Dementia

Share to Infant

Share to Motor Neurons

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36951214
DOI: 10.1111/nan.12902
PMCID: PMC10946706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.PMID 36951214Read ↗

Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD.Semantic proximity Read ↗

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.Semantic proximity Read ↗

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.Semantic proximity Read ↗

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQSemantic proximity Read ↗

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathySemantic proximity Read ↗

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelSemantic proximity Read ↗

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficitsSemantic proximity Read ↗

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Semantic proximity Read ↗

Pathogenesis of FUS-associated ALS and FTD: insights from rodent modelsSemantic proximity Read ↗

Elevating Neuronal <i>CYLD</i> Causes Frontotemporal Dementia (FTD)-Relevant Behavioral and Physiological DeficitsSemantic proximity Read ↗

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.Semantic proximity Read ↗

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.