Article
CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.
Brain : a journal of neurology - 1 Mar 2020
Dobson-Stone Carol, Hallupp Marianne, Shahheydari Hamideh, Ragagnin Audrey M G, Chatterton Zac, Carew-Jones Francine, Shepherd Claire E, Stefen Holly, Paric Esmeralda, Fath Thomas, Thompson Elizabeth M, Blumbergs Peter, Short Cathy L, Field Colin D, Panegyres Peter K, Hecker Jane, Nicholson Garth, Shaw Alex D, Fullerton Janice M, Luty Agnes A, Schofield Peter R, Brooks William S, Rajan Neil, Bennett Mark F, Bahlo Melanie, Landers John E, Piguet Olivier, Hodges John R, Halliday Glenda M, Topp Simon D, Smith Bradley N, Shaw Christopher E, McCann Emily, Fifita Jennifer A, Williams Kelly L, Atkin Julie D, Blair Ian P, Kwok John B
Abstract excerpt
Frontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically overlapping disorders with shared genetic causes. We previously identified a disease locus on chromosome 16p12.1-q12.2 with genome-wide significant linkage in a large European Australian family with autosomal dominant inheritance of frontotemporal dementia and amyotrophic lateral sclerosis and no mutation in known...
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