Article

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology

2026-02-28

Abstract excerpt

Met1-linked ubiquitin chains (Met1-Ub), synthesised by the linear ubiquitin chain assembly complex (LUBAC) and disassembled by the deubiquitinase OTULIN, critically regulate inflammatory signalling. Although OTULIN’s activity is essential to prevent TNF-driven autoinflammatory pathology and embryonic lethality, the regulatory significance of its direct interaction with LUBAC remains unclear. Here, we reveal that m...

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Literature Corpus work: 50d49b60-1e65-5f61-bbd1-c72f39aa2ec0
DOI: 10.64898/2026.02.27.708452

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