Article

Dopaminergic Co-transmission with Sonic Hedgehog Inhibits Abnormal Involuntary Movements

2020-03-10

Abstract excerpt

L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson’s Disease. The mechanistic underpinnings of LID remain obscure. Here we report that diminshed sonic hedgehog (Shh) signaling in the basal ganglia caused by the degeneration of midbrain dopamine neurons (DANs) facilitates the formation and expression of LID. We demonstrate that augmenting Shh signaling with a...

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Literature Corpus work: 0dc4e4b7-847d-5b19-bde3-3ac4e61cb14c
DOI: 10.1101/2020.03.09.983759

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