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Article

Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Oct 2013

Golden Judith P, Demaro Joseph A, Knoten Amanda, Hoshi Masato, Pehek Elizabeth, Johnson Eugene M, Gereau Robert W, Jain Sanjay

Abstract excerpt

The loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and consequent depletion of striatal dopamine are known to underlie the motor deficits observed in Parkinson's disease (PD). Adaptive changes in dopaminergic terminals and in postsynaptic striatal neurons can compensate for significant losses of striatal dopamine, resulting in preservation of motor behavior. In addition, compensatory...

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Identifiers

PMID: 24155314
DOI: 10.1523/JNEUROSCI.0890-13.2013
PMCID: PMC3807031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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