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Article

Duration of Shh signaling contributes to mDA neuron diversity.

Developmental biology - 1 Feb 2013

Hayes Lindsay, Ralls Sherry, Wang Hui, Ahn Sohyun

Abstract excerpt

Sonic hedgehog (Shh) signaling is critical for various developmental processes including specification of the midbrain dopamine (mDA) neurons in the ventral mesencephalon (vMes). While the timing of Shh and its response gene Gli1 segregates mDA neurons, their overall lineage contribution to mDA neurons heavily overlaps. Here, we demonstrate that the same set of mDA neuron progenitors sequentially respond to Shh...

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Identifiers

PMID: 23201023
DOI: 10.1016/j.ydbio.2012.11.016
PMCID: PMC3548960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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