Article
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
Nature - 23 Oct 2003
Berman David M, Karhadkar Sunil S, Maitra Anirban, Montes De Oca Rocio, Gerstenblith Meg R, Briggs Kimberly, Parker Antony R, Shimada Yutaka, Eshleman James R, Watkins D Neil, Beachy Philip A
Abstract excerpt
Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in familial conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the cerebellum and skeletal muscle. Here we show that a wide range of digestive tract tumours, including most of those originating in the oesophagus, stomach, biliary tract and pancreas, but not in the colon, display increased Hh pathway activity,...
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