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Article

Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features.

International journal of cancer - 15 Dec 2025

Yu Zhijun, Derksen Merel, Te Pas Brigit M, Ladstätter Sabrina, Overmeer Rene, Brazda Peter, van de Wetering Marc, Pourfarzad Farzin, Vries Robert G J, Megchelenbrink Wout, Bock Christoph, Altucci Lucia, Stunnenberg Hendrik G

Abstract excerpt

Colorectal cancer (CRC) arises in the colorectal tissue driven by genetic disorder or the accumulation of somatic mutations, leading to abnormal epithelial cell growth. In this study, we employed single-nucleus multi-omics analysis, including single-nucleus RNA-seq and single-nucleus ATAC-seq, on over 100,000 high-quality nuclei to investigate the molecular landscape of both primary tissue and patient-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40847690
DOI: 10.1002/ijc.70103
PMCID: PMC12541563

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