Article

OXR1 maintains the retromer to delay brain aging under dietary restriction

2022-04-07

Abstract excerpt

<title>Abstract</title> <p>Dietary restriction (DR) delays aging and neurodegeneration, but the mechanisms behind this remain to be elucidated. We identified genetic polymorphisms in mustard (mtd), the fly homolog of Oxidation resistance 1 (OXR1), which influenced lifespan and mtd expression in neurons in response to DR regulated by the transcription factor Traffic jam (TJ). Knockdown of mtd inhibited DR-mediated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0dba21ea-6440-5e9c-9674-2b8d38e0da9d
DOI: 10.21203/rs.3.rs-1455343/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

OXR1 maintains the retromer to delay brain aging under dietary restrictionDOI 10.21203/rs.3.rs-1455343/v1Read

Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction.Semantic proximity Read

Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration.Semantic proximity Read

Dietary fiber supplementation increases Drosophila melanogaster lifespan and gut microbiota diversitySemantic proximity Read

Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.Semantic proximity Read

The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Semantic proximity Read

Dietary methionine restriction started late in life promotes healthy aging in a sex-specific mannerSemantic proximity Read

Suppressing APOE4-induced mortality and cellular damage by targeting VHLSemantic proximity Read

Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of agingSemantic proximity Read

Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in DrosophilaSemantic proximity Read

Lysosomal Enhancement Prevents Infection with PrP <sup>Sc</sup> , α-Synuclein & Tau PrionsSemantic proximity Read

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase TranscriptionSemantic proximity Read

Dietary Restriction Fails to Extend Lifespan of <i>Drosophila</i> Model of Werner SyndromeSemantic proximity Read