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Article

Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.

PLoS genetics - 1 Jan 2012

Wuttke Daniel, Connor Richard, Vora Chintan, Craig Thomas, Li Yang, Wood Shona, Vasieva Olga, Shmookler Reis Robert, Tang Fusheng, de Magalhães João Pedro

Abstract excerpt

Dietary restriction (DR), limiting nutrient intake from diet without causing malnutrition, delays the aging process and extends lifespan in multiple organisms. The conserved life-extending effect of DR suggests the involvement of fundamental mechanisms, although these remain a subject of debate. To help decipher the life-extending mechanisms of DR, we first compiled a list of genes that if genetically altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22912585
DOI: 10.1371/journal.pgen.1002834
PMCID: PMC3415404

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