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Article

Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration.

Cell metabolism - 1 Dec 2010

Reilly Shannon M, Bhargava Prerna, Liu Sihao, Gangl Matthew R, Gorgun Cem, Nofsinger Russell R, Evans Ronald M, Qi Lu, Hu Frank B, Lee Chih-Hao

Abstract excerpt

The transcriptional corepressor SMRT utilizes two major receptor-interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification. The physiological significance of such interaction remains unclear. We find SMRT expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues....

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Identifiers

PMID: 21109196
DOI: 10.1016/j.cmet.2010.11.007
PMCID: PMC3033658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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