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Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut

1 Jan 2019

Abstract excerpt

The secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), formed by gut microbiota from primary bile acids via a multi-step 7α-dehydroxylation reaction, have wide-ranging effects on host metabolism and play an important role in health and disease. A few 7α-dehydroxylating strains have been isolated, where bile acid-inducible ( bai ) genes were organized in a gene cluster and encoded major...

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PMID: 31428294
DOI: 10.1016/j.csbj.2019.07.012

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