Article

Completion of the gut microbial epi-bile acid pathway

2020-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Bile acids are detergent molecules that solubilize dietary lipids and lipid-soluble vitamins. Humans synthesize bile acids with α-orientation hydroxyl groups which can be biotransformed by gut microbiota to toxic, hydrophobic bile acids, such as deoxycholic acid (DCA). Gut microbiota can also convert hydroxyl groups from the α-orientation through an oxo-intermediate to the β-orientation, resulti...

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Literature Corpus work: 27c3c6d3-b4aa-5f66-a9a2-0f0cda067ac1
DOI: 10.1101/2020.09.27.315549

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