Article

Severe and regionally-widespread increases in tissue urea in the human brain represent a novel finding of pathogenic potential in Parkinson’s disease dementia

2021-04-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Widespread elevations in brain urea have, in recent years, been reported in certain types of age-related dementia, notably Alzheimer’s disease (AD) and Huntington’s disease (HD). Urea increases in these diseases are substantive, and approximate in magnitude to levels present in uraemic encephalopathy. In AD and HD, elevated urea levels occur across the entire br...

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Literature Corpus work: 1a00288f-119f-5058-ac86-d30eab2a9e3d
DOI: 10.21203/rs.3.rs-435222/v1

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