Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The degeneration and replacement of dopamine cells in Parkinson’s disease: the role of aging

7 Aug 2014

Abstract excerpt

Available data show marked similarities for the degeneration of dopamine cells in Parkinson's disease (PD) and aging. The etio-pathogenic agents involved are very similar in both cases, and include free radicals, different mitochondrial disturbances, alterations of the mitophagy and the ubiquitin-proteasome system. Proteins involved in PD such as α-synuclein, UCH-L1, PINK1 or DJ-1, are also involved in aging. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25147507
DOI: 10.3389/fnana.2014.00080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The degeneration and replacement of dopamine cells in Parkinson’s disease: the role of agingPMID 25147507Read ↗

[Parkinson disease: mechanisms of cell death].Semantic proximity Read ↗

Novel Therapeutics in the Search for Disease Modification in Parkinson’s Disease – a Rapid Review of the LiteratureSemantic proximity Read ↗

Etiology and pathogenesis of Parkinson's diseaseSemantic proximity Read ↗

Parkinson's disease as a result of agingSemantic proximity Read ↗

Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s DiseaseSemantic proximity Read ↗

Aging, cellular senescence and Parkinson's diseaseSemantic proximity Read ↗

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.Semantic proximity Read ↗

Is Parkinson's really a disease? Reframing it as a phenotype of aging.Semantic proximity Read ↗

Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants.Semantic proximity Read ↗

The hallmarks of Parkinson's disease.Semantic proximity Read ↗

Molecular pathogenesis, experimental models and new therapeutic strategies for Parkinson's disease.Semantic proximity Read ↗

The cell biology of Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.