Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering Mutations.

Molecular biology and evolution - 1 Oct 2015

Sabater-Muñoz Beatriz, Prats-Escriche Maria, Montagud-Martínez Roser, López-Cerdán Adolfo, Toft Christina, Aguilar-Rodríguez José, Wagner Andreas, Fares Mario A

Abstract excerpt

Molecular chaperones fold many proteins and their mutated versions in a cell and can sometimes buffer the phenotypic effect of mutations that affect protein folding. Unanswered questions about this buffering include the nature of its mechanism, its influence on the genetic variation of a population, the fitness trade-offs constraining this mechanism, and its role in expediting evolution. Answering these questions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chaperonin 60
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Genes, Bacterial

Share to Genetic Drift

Share to Genetic Fitness

Share to Operon

Share to Subcellular Fractions

Source

Open in PubMed Open full text

Identifiers

PMID: 26116858
DOI: 10.1093/molbev/msv144
PMCID: PMC4576708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering Mutations.PMID 26116858Read ↗

GroEL/S Overexpression Helps to Purge Deleterious Mutations and Reduce Genetic Diversity during Adaptive Protein Evolution.Semantic proximity Read ↗

Chaperonin overexpression promotes genetic variation and enzyme evolution.Semantic proximity Read ↗

RNA chaperones buffer deleterious mutations in E. coli.Semantic proximity Read ↗

GroEL/ES buffering and compensatory mutations promote protein evolution by stabilizing folding intermediates.Semantic proximity Read ↗

Interplay between chaperones and protein disorder promotes the evolution of protein networks.Semantic proximity Read ↗

Selection for chaperone-like mediated genetic robustness at low mutation rate: impact of drift, epistasis and complexity.Semantic proximity Read ↗

Endosymbiotic bacteria: groEL buffers against deleterious mutations.Semantic proximity Read ↗

Predicting the effect of mutations to investigate recent events of selection across 60,472 Escherichia coli strains.Semantic proximity Read ↗

Mutational robustness and the role of buffer genes in evolvability.Semantic proximity Read ↗

GROEL/ES Buffers Entropic Traps in Folding Pathway during Evolution of a Model Substrate.Semantic proximity Read ↗

Evolutionary stalling and a limit on the power of natural selection to improve a cellular module.Semantic proximity Read ↗

High-throughput characterization of mutations in genes that drive clonal evolution using multiplex adaptome capture sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.