Article

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

2019-06-21

Abstract excerpt

USP5 disassembles unanchored polyubiquitin chains to recycle free mono-ubiquitin, and is one of twelve ubiquitin-specific proteases featuring a zinc finger ubiquitin-binding domain (ZnF-UBD). This distinct structural module has been associated with substrate positioning or allosteric modulation of catalytic activity, but its cellular function remains unclear. We screened a chemical library focused on the ZnF-UBD o...

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Literature Corpus work: 22171854-c2d8-5754-ae0b-084d567838e7
DOI: 10.1101/676668

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