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Integration of transcriptomics and proteomics uncovers novel targets underlying the protective effects of Nrf2 knockout in HEI-OC1 cells

2023-10-30

Abstract excerpt

<title>Abstract</title> <p>Cisplatin, a utilized anticancer drug in clinical practice, induces sensorineural hearing loss (SNHL) in patients. However, the precise mechanism underlying cisplatin-associated ototoxicity remains unknown. HEI-OC1 cells are immortalized cells derived from the organs of Corti mice and nuclear factor erythroid 2-related factor 2 （Nrf2） knockout (KO) significantly enhances cisplatin resis...

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Literature Corpus work
0d589427-bcb8-59ac-84b4-598113747f16
DOI
10.21203/rs.3.rs-3479946/v1
Open publication

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Integration of transcriptomics and proteomics uncovers novel targets underlying the protective effects of Nrf2 knockout in HEI-OC1 cellsDOI 10.21203/rs.3.rs-3479946/v1
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