Article

Effect of Downregulated Citrate Synthase on Oxidative Phosphorylation Signaling Pathway in HEI-OC1 Cells

2022-07-12

Abstract excerpt

<h4>Background: </h4> Citrate Synthase ( Cs ) gene mutation (locus ahL4 ) has been found to play an important role in progressive hearing loss of A/J mice. HEI-OC1 cells have been widely used as an in vitro system to study cellular and molecular mechanisms related to hearing lose. We previously reported the increased apoptosis and the accumulation of reactive oxygen species (ROS) in shRNACs-1429 cells, a Cs low-ex...

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Literature Corpus work: 0e2b4622-e548-514d-8ea5-4060e2ebf116
DOI: 10.21203/rs.3.rs-1796280/v1

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