Article

Computational Modeling of Effects of <i>PKP2</i> Gene Therapy on Ventricular Conduction Properties in Arrhythmogenic Cardiomyopathy

2024-12-17

Abstract excerpt

<h4>Background</h4> Patients with arrhythmogenic cardiomyopathy (ACM) due to pathogenic variants in PKP2 , the gene for the desmosomal protein plakophilin-2, are being enrolled in gene therapy trials designed to replace the defective allele via adeno-associated viral (AAV) transduction of cardiac myocytes. Evidence from experimental systems and patients indicates that ventricular myocytes in PKP2 ACM have great...

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Literature Corpus work: 0d4e4b15-eeb5-540d-ac86-2caf89630221
DOI: 10.1101/2024.12.12.628155

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