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Article

Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.

Cardiovascular research - 1 Sept 2012

Cerrone Marina, Noorman Maartje, Lin Xianming, Chkourko Halina, Liang Feng-Xia, van der Nagel Roel, Hund Thomas, Birchmeier Walter, Mohler Peter, van Veen Toon A, van Rijen Harold V, Delmar Mario

Abstract excerpt

AIMS: The shRNA-mediated loss of expression of the desmosomal protein plakophilin-2 leads to sodium current (I(Na)) dysfunction. Whether pkp2 gene haploinsufficiency leads to I(Na) deficit in vivo remains undefined. Mutations in pkp2 are detected in arrhythmogenic right ventricular cardiomyopathy...

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Source

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Identifiers

PMID: 22764151
DOI: 10.1093/cvr/cvs218
PMCID: PMC3422082

Genes

PKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22764151-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.PMID 22764151Read ↗

Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.Semantic proximity Read ↗

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Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards StressSemantic proximity Read ↗

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Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond DesmosomesSemantic proximity Read ↗

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Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.Semantic proximity Read ↗

Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy.Semantic proximity Read ↗

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