Article
Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy.
Circulation. Heart failure - 1 Apr 2026
Zhang Jing, Zanella Fabian, Ellis Matthew W, Bradford William H, Gutierrez-Lara Erika Joana, Wang Tsui-Min, Fujita Kyohei, Duron Charlize, Karakikes Ioannis, Lyon Robert C, Mezzano Valeria, Roberts Jason D, Carromeu Cassiano, Gu Yusu, Martin Jody L, Muotri Alysson R, Scheinman Melvin M, Peterson Kirk L, Sheikh Farah
Abstract excerpt
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is a fatal genetic heart disease primarily caused by mutations in desmosomal genes, leading to impaired cell-cell adhesion, ventricular arrhythmias, and progressive heart failure. Although gene therapy for specific ACM populations shows promise, it remains unclear whether mutation-agnostic pathways dysregulated across desmosomal mutations could be exploited for...
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