Article
Reversal of potassium channel deficiency in cells from failing hearts by adenoviral gene transfer: a prototype for gene therapy for disorders of cardiac excitability and contractility.
Gene therapy - 1 Oct 1996
Nuss H B, Johns D C, Kääb S, Tomaselli G F, Kass D, Lawrence J H, Marban E
Abstract excerpt
Heart failure is a common, often lethal disorder in which conventional pharmacologic strategies have achieved limited success. Failing hearts exhibit a delay of electrical repolarization which predisposes to fatal arrhythmias. To explore the feasibility of gene therapy for this condition, we isolated myocytes from normal and failing dog hearts and quantified electrophysiologic and contractile parameters in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.