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Cardiac AAV9:PKP2 Gene Therapy Reduces Ventricular Arrhythmias, Reverses Adverse Remodeling, and Reduces Mortality in a Mouse Model of ARVC

2023-05-24

Abstract excerpt

<title>Abstract</title> <p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause of this disease. Mutations in desmosome gene Plakophilin-2 (PKP2) account for 45% of ARVC cases and result in reduced gene expressi...

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Literature Corpus work
86b7a7ad-c40d-5ef0-a4a9-ab5706a96cd7
DOI
10.21203/rs.3.rs-2958419/v1
Open publication

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Cardiac AAV9:PKP2 Gene Therapy Reduces Ventricular Arrhythmias, Reverses Adverse Remodeling, and Reduces Mortality in a Mouse Model of ARVCDOI 10.21203/rs.3.rs-2958419/v1
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