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Article

Basal epithelial stem cells are efficient targets for prostate cancer initiation

25 Jan 2010

Abstract excerpt

Prevailing theories suggest that luminal cells are the origin of prostate cancer because it is histologically defined by basal cell loss and malignant luminal cell expansion. We introduced a series of genetic alterations into prospectively identified populations of murine basal/stem and luminal cells in an in vivo prostate regeneration assay. Stromal induction of FGF signaling, increased expression of the ETS...

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Identifiers

PMID: 20133806
DOI: 10.1073/pnas.0913873107

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