Article

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

2020-04-05

Abstract excerpt

While cancer is commonly perceived as a disease of dedifferentiation, the hallmark of early stage prostate cancer is paradoxically the loss of more plastic basal cells and the abnormal proliferation of more differentiated secretory luminal cells. However, the mechanism of prostate cancer pro-luminal differentiation is largely unknown. Through integrating analysis of the transcription factors (TFs) from 806 human p...

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Literature Corpus work: a041c0d2-1830-529d-a53c-d995a0d2d273
DOI: 10.1101/2020.04.03.024349

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