Article
Mutations in catalase-peroxidase KatG from isoniazid resistant Mycobacterium tuberculosis clinical isolates: insights from molecular dynamics simulations.
Journal of molecular modeling - 1 Apr 2017
Pimentel Arethusa Lobo, de Lima Scodro Regiane Bertin, Caleffi-Ferracioli Katiany Rizzieri, Siqueira Vera Lúcia Dias, Campanerut-Sá Paula Aline Zanetti, Lopes Luciana Dias Ghiraldi, de Almeida Aryadne Larissa, Cardoso Rosilene Fressatti, Seixas Flavio Augusto Vicente
Abstract excerpt
The current multidrug therapy for tuberculosis (TB) is based on the use of isoniazid (INH) in combination with other antibiotics such as rifampin, ethambutol and pyrazinamide. Literature reports have shown that Mycobacterium tuberculosis, the causative agent of TB, has become resistant to this treatment by means of point mutations in the target enzymes of these drugs, such as catalase-peroxidase (KatG). By means...
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