Article

Critical slowing down at the neuromuscular junction: an early-warning framework for amyotrophic lateral sclerosis

2026-08-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective.</bold> In amyotrophic lateral sclerosis (ALS), disease is monitored largely through accumulated loss. We develop the hypothesis that the stability of the compensation offsetting that loss carries an earlier signal than the level of loss itself, readable as a critical-slowing-down (CSD) signature from instability measures already recorded serially. <bold>Methods.</bo...

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Literature Corpus work: 0d14dd98-6272-5a6c-b634-defa194737c8
DOI: 10.21203/rs.3.rs-10642034/v1

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