Article

Maximising the translational potential of neurophysiology in amyotrophic lateral sclerosis: a study on compound muscle action potentials

2024-05-10

Abstract excerpt

Transgenic mouse models of amyotrophic lateral sclerosis, such as the widely used SOD1 G93A mouse, enable investigation of disease mechanisms and testing of novel therapeutic interventions. However, treatments that have been considered successful in mice have often failed to translate into human benefit in clinical trials, particularly when relying on the so-called ‘survival’ read-out. Compound muscle action pote...

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Literature Corpus work: db91d98e-f528-58f5-ad74-c84b2102ec49
DOI: 10.1101/2024.05.09.593349

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