Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

First-recruited motor units adopt a faster phenotype in amyotrophic lateral sclerosis.

The Journal of physiology - 1 Sept 2021

Weddell Thomas, Bashford James, Wickham Aidan, Iniesta Raquel, Chen Maoqi, Zhou Ping, Drakakis Emmanuel, Boutelle Martyn, Mills Kerry, Shaw Chris

Abstract excerpt

KEY POINTS: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder of motor neurons, carrying a short survival. High-density motor unit recordings permit analysis of motor unit size (amplitude) and firing behaviour (afterhyperpolarization duration and muscle fibre conduction velocity). Serial recordings from biceps brachii indicated that motor units fired faster and with greater amplitude...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Electromyography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Neurons

Share to Muscle, Skeletal

Share to Phenotype

Source

Identifiers

PMID: 34261189
DOI: 10.1113/JP281310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

First-recruited motor units adopt a faster phenotype in amyotrophic lateral sclerosis.PMID 34261189Read ↗

SPiQE: an automated analytical tool for detecting and characterising fasciculations in amyotrophic lateral sclerosisSemantic proximity Read ↗

Upregulation of persistent sodium conductances in familial ALSSemantic proximity Read ↗

Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosisSemantic proximity Read ↗

Nerve excitability measured with the TROND protocol in amyotrophic lateral sclerosis: a systematic review and meta-analysisSemantic proximity Read ↗

Differential motor neuron impairment and axonal regeneration in sporadic and familiar amyotrophic lateral sclerosis with SOD-1 mutations: lessons from neurophysiology.Semantic proximity Read ↗

Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.Semantic proximity Read ↗

Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neuronsSemantic proximity Read ↗

Maximising the translational potential of neurophysiology in amyotrophic lateral sclerosis: a study on compound muscle action potentialsSemantic proximity Read ↗

Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons.Semantic proximity Read ↗

Circular continuum of alpha motoneuron typesSemantic proximity Read ↗

Cortical inexcitability in ALS: correlating a clinical phenotype.Semantic proximity Read ↗

Spontaneous activity in electromyography may differentiate certain benign lower motor neuron disease forms from amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.