Article

A contraction index for protein stability predicts disease onset in stability-driven amyloidoses and identifes its own boundary of validity

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>The product σ = D · γ of two folding-funnel parameters—the fraction of productive conformational moves (D) and the step-wise contraction ratio (γ)—defnes a stability index anchored at a common reference point (σ = 1): σ < 1 corresponds to a contractive native basin; σ > 1 corresponds to loss of contractivity. We hypothesize that σ is pre- dictive of pathogenicity and clinical onset when...

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Literature Corpus work: 6e4771b8-6a9b-506e-894f-6185a3446a1a
DOI: 10.21203/rs.3.rs-9247072/v1

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