Article

Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma by activation of YAP signaling

2022-02-17

Abstract excerpt

Chondrosarcoma (CHS) is a rare type of soft sarcoma with increased production of cartilage matrix arising from soft bone tissues. Currently, surgical resection is the primary clinical treatment for chondrosarcoma due to the poor response to radiotherapy and chemotherapy. However, the therapeutic effect is not satisfactory due to the higher local recurrence rate. Thus, management and elucidation of the pathological...

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Literature Corpus work: 0d114514-dc3c-5af3-b5fc-e49a2f3270ea
DOI: 10.21203/rs.3.rs-1346590/v1

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