Article
New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2013
Monderer David, Luseau Alexandrine, Bellec Amélie, David Emmanuelle, Ponsolle Stéphanie, Saiagh Soraya, Bercegeay Sylvain, Piloquet Philippe, Denis Marc G, Lodé Laurence, Rédini Françoise, Biger Marine, Heymann Dominique, Heymann Marie-Françoise, Le Bot Ronan, Gouin François, Blanchard Frédéric
Abstract excerpt
Chondrosarcomas are cartilage-forming, poorly vascularized tumors. They represent the second malignant primary bone tumor of adults after osteosarcoma, but in contrast to osteosarcoma they are resistant to chemotherapy and radiotherapy, surgical excision remaining the only therapeutic option. Few cell lines and animal models are available, and the mechanisms behind their chemoresistance remain largely unknown....
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