Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.

doi:10.1158/1078-0432.CCR-23-1703

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Article

Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2023

Denu Ryan A, Yang Richard K, Lazar Alexander J, Patel Shalin S, Lewis Valerae O, Roszik Jason, Livingston J Andrew, Wang Wei-Lien, Shaw Kenna R, Ratan Ravin, Zarzour Maria A, Bird Justin, Raza Shaan, Akdemir Kadir C, Rodon Ahnert Jordi, Subbiah Vivek, Patel Shreyaskumar, Conley Anthony P

Abstract excerpt

PURPOSE: Chondrosarcomas are the most common primary bone tumor in adults. Isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations are prevalent. We aimed to assess the clinico-genomic properties of IDH mutant versus IDH wild-type (WT) chondrosarcomas as well as alterations in other genes. EXPERIMENTAL DESIGN: We included 93 patients with conventional and dedifferentiated chondrosarcoma for which there were...

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PMID: 37747813
DOI: 10.1158/1078-0432.CCR-23-1703
PMCID: PMC10835757

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