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Article

Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel.

Nature communications - 9 Oct 2020

Wilson Daniel M, Li Yu, LaPeruta Amber, Gamalinda Michael, Gao Ning, Woolford John L

Abstract excerpt

The nascent polypeptide exit tunnel (NPET) is a major functional center of 60S ribosomal subunits. However, little is known about how the NPET is constructed during ribosome assembly. We utilized molecular genetics, biochemistry, and cryo-electron microscopy (cryo-EM) to investigate the functions of two NPET-associated proteins, ribosomal protein uL4 and assembly factor Nog1, in NPET assembly. Structures of...

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PMID: 33037216
DOI: 10.1038/s41467-020-18878-8
PMCID: PMC7547690

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