Article

Inhibitors of gut bacterial L-dopa decarboxylation with reduced susceptibility to host metabolism

2026-04-09

Abstract excerpt

Microorganisms in the human gut influence the efficacy and metabolism of host-targeted small molecule therapeutics, including the frontline Parkinson’s disease drug levodopa (L-dopa). Previous work has identified a mechanism-based inhibitor of gut bacterial decarboxylases that degrade L-dopa, α-fluoromethyltyrosine (AFMT). However, early experiments with AFMT in rodent models suggested undesirable in vivo metabol...

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Literature Corpus work: 0cffffcb-5366-52fc-85a2-a3e42bf81168
DOI: 10.64898/2026.04.08.717077

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